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The supernatural grudge manifests itself by way of a strange cyst growing in the body of a young woman, slowly draining all life from her in revenge for... what?

An apparitions of a young schoolgirl in a yellow rain hat, a family massacre, and a law student's suicide after he fails his bar exam are linked by the ominous recordings discovered on an audio cassette.

Dr. Hattori and her husband watch footage of brain surgery experiments with Manchurian, Russian and Japanese guinea pigs that had been found in the basement of a wrecked hospital. Out of the blue, there is a white light and when they look back, they see they children Ota Miyuki and Kaori staring at the light. Years later, Miyuki vanishes from the Tama Medical University Hospital and her sister Kaori, Miyuki's boyfriend Motojima and detective Hirasawa are seeking her. However, Miyuki and the teenagers Kazochi, Takumi, Hattori and Rieko have been submitted to a nightmarish experiment by Dr. Hattori and her team with tragic results.

Kageko, a teacher in a small mountain village with a thriving Japanese paper industry, is visited by a former student, who proposes a plan to manufacture counterfeit money. She initially refuses, but eventually decides to join the project for the sake of the poor children in the village and her own mentally handicapped child.

Miri Asano, a second-year junior high school student who makes a wish for a star, is given a protect suit "bloomers" by a human-sized rabbit, Yun, and becomes a "space girl detective bloomers" by "flashing". Her enemy is the Dark Dimension Empire Enigma. The ruler, Emperor of Darkness, Destruction God Baower, led a fleet of different dimensions and started invading the earth. An invading hand approaching Miri's school! Fight! Space Girl Detective Bloomers!

Sequel to MAD Video and Cell's Death Women